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AS 2553627
CAS No. 1251906-07-6
AS 2553627 ( AS2553627 | AS-2553627 )
产品货号. M11009 CAS No. 1251906-07-6
AS 2553627 (AS2553627) 是一种新型有效的选择性泛 JAK 抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称AS 2553627
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述AS 2553627 (AS2553627) 是一种新型有效的选择性泛 JAK 抑制剂。
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产品描述AS 2553627 (AS2553627)?is a novel potent, selective pan-JAK inhibitor with IC50 of 0.46, 0.30, 0.14 and 2.0 nM for JAK1, JAK2, JAK3 and TYK2, respectively; displays no inhibitory activity against a panel of protein kinases, including SYK and ZAP70 at 1 uM; inhibits proliferation of IL-2 stimulated human and rat T cells with IC50 of 2.4 and 4.3 nM, respectively, inhibits the proliferation of TF-1 cells stimulated with EPO with IC50 of 12 nM; effectively prevents chronic rejection in rat cardiac allografts in rat cardiac transplant model alone or co-administration with tacrolimus.
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体外实验——
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体内实验——
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同义词AS2553627 | AS-2553627
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通路Angiogenesis
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靶点JAK
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受体JAK
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研究领域——
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适应症——
化学信息
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CAS Number1251906-07-6
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分子量321.384
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分子式C18H19N5O
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称3-((3R,4R)-3-(dipyrrolo[2,3-b:2',3'-d]pyridin-1(6H)-yl)-4-methylpiperidin-1-yl)-3-oxopropanenitrile
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Nakamura K, et al. Eur J Pharmacol. 2017 Feb 5;796:69-75.
2. Nakamura K, et al. Transpl Immunol. 2017 Oct 5. pii: S0966-3274(17)30038-2.
产品手册
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